What problems does the test find?
A high level of AFP may indicate a problem with the spinal cord, brain, or digestive system. Examples of problems that can cause a high AFP are: Spina bifida, kidney problems, severe skin problems, severe chromosome problems (other than Down syndrome), anencephaly, a failure of your baby’s abdomen to close, so that the intestines are enclosed in a sac outside the abdomen a defect in the esophagus (food pipe).
A low level of the protein may indicate Down syndrome. Other possible causes for abnormal levels are: An incorrect due date, the presence of more than 1 baby, miscarriage, a pulling away of the placenta from the uterus, a baby who is smaller than normal, an overweight mother, especially if the mother is African American, or a diabetic mother.